The reason for this is due to an increase in kinetic energy. 20g of aspirin was produced. Overall this shows that the experiment was a success as a large amount of aspirin was produced, however these results also showed that there was major errors or inefficiencies in the experiment. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. 66, 2116 – 20. This is a possible source of error that would lead to a less consistent time and wider data spread/greater standard deviation. ? It was not digital and did had a disk shaped scale. To synthesise aspirin from 2- hydroxybenzoic acid Safety Specification links Perform the experiment in a well-ventilated room. z�`�U�3lj ? Beaker 1 +/- 100 ml ? Therefore moles acetylsalicylic acid (aspirin) = 0. Wait and observe a little longer until all of the aspirin has melted. The personal times measured for the rise in temperature are relatively accurate in relation to the class average results, as the recorded times fall within one standard deviation of the mean. The reactants: In the experiment that was carried out the reactants were not measured by the apprentices. 7 g in a very small test tube. Salicylic acid and acetic anhydride have heats of solvation in water, so aqueous catalyst would change the reaction’s rate of temperature change relative to the non-aqueous catalyst even if the catalysts were equally effective. Gently heat the Quick-fit flask mixture for 30 minutes at 70 degrees.

Pipette ? Jack/ Lift ? Thus, unknown compound B was determined to be impure acetylsalicylic acid. Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. Add 10 mL of Carry out a microscale esterification reaction between 2-hydroxybenzoic acid (salicylic acid) and ethanoic anhydride using phosphoric acid as a catalyst to produce aspirin on a microscale. The solubility of aspirin in water increases as the temperature increases. Acetic acid is a byproduct of the reaction. Practical assessment. This site uses cookies from Google and other third parties to deliver its services, to personalise adverts and to analyse traffic. Place the test tube in the melting point apparatus checker. The general mechanism for catalysation by a base, like the acetate ion or pyridine, is shown in Figure 2. use better apparatus that are 100% efficient ? ����zV��e �,r��}�CCM9���nP�"���ST>4 As the kinetic energy increase, molecules move faster and collide with other molecules, therefore there are more interactions. At 37°C 1g of aspirin is soluble in 100g of water. To most directly measure rate, the concentration of a product should be measured periodically over time. Shape of aspirin depending on the size and dosage (in industry) ? What Is the Chemical Equation for the Synthesis of Aspirin.

H 3PO 4 C 4H 6O 3 + C 7H 6O 3 → C 9H 8O 4 + HC 2H 3O 2 Acetic Salicylic Aspirin Acetic Acid Anhydride Acid This can be expanded to the following structures: Note: Carbons (and hydrogens) are implied where lines (bonds) meet. 3623 mol + 0. salicylic acid (salicylate ion) to give a purple solution. [online]. What is the melting point of aspirin?

As a result the action of condensing was not 100% efficient.

Aspirin is an analgesic (pain reliever), an antipyretic (fever reducer), and anti-inflammatory medicine. Yield of acetylsalicylic acid. Assess learning with questions about the reactions of alkanes and alcohols.

Endothermic side reactions would retard the rate of temperature increase. Calculate the yield. Monitoring the rate of a reaction via temperature change is not the most accurate method of measuring reaction rate because it is so indirect. Balance ? A “purified product” can be obtained through recrystallization of the crude product in hot, Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as, a pain killer. 56. The experiment has been carried out on a small laboratory scale. ? �.�T� Z��S@xM���.��� C��P�;}�bW-u۞^�,��h���,i� lj�cV�2 dҷ���(H�7�g^p��H0'�~T I�@�%Rp��NK\� ���:�.CL�@�ԋM�j{s�woa�_��<3���T��{��m����2f�k^@�ao��I#Ț�%�xl���E-�n����&�K�UF�+���m�����Ș ��Ƕ9����k�ź���ޠ�X_M/]G���.��m_���歝�p��o��� ��

Nomenclature List with Units m = Mass (measured in grams) n = Number of Moles (Mol) Mr = relative molecular mass Mol = Number of moles Apparatus: ? our expert writers, Hi, my name is Jenn Apply knowledge in context and assess learning with questions exploring condensation polymerisation, including polyesters and the nylon rope trick experiment. Members of the class may have also utilized different techniques to measure the time taken for a 4 ˚C temperature change to occur. Assess learning with questions exploring the topic of burning hydrocarbons.

Generally take more care with the experiment. endobj The equilibrated thermometer was immediately placed into the reaction solution and the initial temperature on the thermometer was noted.

Discussion and Interpretation: Analysing the results obtained it is clear that the experiment was a success. Student worksheets at higher level.

Principle: Synthesis of aspirin from salicylic acid occurs by acetylation process in acidic medium. However when 70°C was reached and the heater was turned off, it was observed that the temperature on the thermometer had risen around 10°C more after this point. Sulfuric acid increased the rate of reaction the most by reducing the energy of the reaction’s transition state(s) and thus lowering the reaction’s activation energy. 2-hydroxybenzoic acid is harmful.

Lower absorbance values would indicate that a greater concentration of phenol was present and the absorbance value could be used to directly determine the concentration, 1 Cappelli, G. J. Chem. Wear heat-protective gloves when handling hot equipment. A small amount of a strong acid is used as a catalyst that speeds up the reaction. Beaker 2 +/- 100ml ? Additionally, the exothermic reaction of salicylic acid acetylation is not the sole process influencing the temperature, as the method assumes. The physics of restoration and conservation, Changes to Education in Chemistry subscriptions, The microscale synthesis of aspirin - teacher, The microscale synthesis of aspirin - student, (b) principles underlying the techniques of manipulation, separation and purification used in organic chemistry, PRACTICAL: Synthesis of a solid organic product, including recrystallisation and determination of melting temperature, Unit A2 2: Analytical, Transition Metals, Electrochemistry and Organic Nirtrogen Chemistry. App. If salicylic acid is present, the test will turn a deep purple color, Add all chemicals to the round-bottomed flask and setup the heating bath. ? Aspirin (acetylsalicylic acid) is the most common medicinal drug in use today. RP 10: Preparation of: a pure organic solid and test of its purity, a pure organic liquid. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. Wear a lab coat and use eye protection. Clamp ? Stirrer ? Mass of beaker = 166. Although there were many errors it was a surprising to get a yield of around 80%. This could be reason as for why the there was a great temperature difference in the melting points of aspirin, The solubility of aspirin in water varies with temperature. Figure 2. 22) * 100 = 86. Synthesis of Aspirin INTRODUCTION Aspirin is one of the milder and least expensive pain relievers available.

750 ml of cold water ? Salicylic acid, whose name comes from Salix, the willow family of plants, was derived fromwillow bark extracts. endobj The solution was cooled slowly to room temperature, then transferred to an ice-water bath. Place the contents into a beaker with around 750 ml of cool water. Raw data used in calculations is available upon request.

? [i] ? The report tests the melting point of the aspirin produced compared to textbook values as tests the amount of yield produced. In thisexperiment, phosphoric acid will be used as the catalyst.

Essay, Use multiple resourses when assembling your essay, Get help form professional writers when not sure you can do it yourself, Use Plagiarism Checker to double check your essay, Do not copy and paste free to download essays. 0g ? Any information that is included in the report will be referenced at the end. Enthalpies of other side reactions, such as the polymerization of salicylic acid may have also contributed to the temperature change, corrupting the data. Read our policy. If necessary remove the heater and carefully shake the mixture ensuring you do not get burnt or hurt. Although this sounds far fetched it was still a flaw in the experiment. Fact Check: What Power Does the President Really Have Over State Governors? ), The Secret Science of Solving Crossword Puzzles, Racist Phrases to Remove From Your Mental Lexicon.

The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. Zn&�O���*= �X�*�(�̟��ݽ�*'�+}1���64�l��R�UI�������٬���}v!�!�^G�b5U�n_�b�D^�H�[�����?���X�Z,���9�e&���Z�hg}V��A�s��M�98�AX����� Packaging (in industry) Conclusion and Recommendations Overall the experiment was a success, considering the flaws in the experiment such as the apparatus and time. It is used to treat pain, reduce fever, and to decrease the aggregation of platelets, such as to decrease blood clotting. �gz�܁]"��K�e]��u�H1�1��6p�����7��^}�{J��0HL��ϔ�|���#f_�j �b���r�z���g���O��C�B+y�L�5�U�P�����&pQ8)�6yr�G�d)ʢ ��B�虼wy��@�*��M����ċ{R�x]��O�#�-��r=U���]G�nH�& #����g>V��DV l�V-�E�@�Kxk�T[�o�k���z��A�V�B�dA�{e�!G��y�OUl}|�ve,59�[�0��s�;�-�/��+�������r-�SH��� ��**��h-��%�� Ҫ�]�(�

The time values for each reaction were averaged with the other class values and standard deviation was calculated. Salicylic acid (1.00 g + 0.005 g) and acetic anhydride (2.0 mL + 0.05 mL) were added to each of four test tubes. 3 0 obj

Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.